Our pharmacist answer the recent question about whether or not your deserve to take Benadryl (diphenhydramine) with Nyquil.

You are watching: Can i take benadryl and nyquil together



At a glance

NyQuil has doxylamine, a sedating first-generation antihistamine. Benadryl includes diphenhydramine, likewise a sedating first-generation antihistamine. Use of both together rises the risk of side impacts such together oversedation, dry mouth, dried eyes and constipation.



In many cases, it is not encourage to take it Benadryl (diphenhydramine) and also Nyquil together due to the fact that they both contain sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, which is an extremely closely pertained to diphenhydramine (the active ingredient in Benadryl). In fact, they space in the same class of medication, sedating first-generation antihistamines.

Taking two first-generation antihistamines together is considered "duplicate therapy" and increases the threat of side impacts occurring.

What Is Benadryl?

Benadryl is classified as a first generation antihistamine. The expression of activity of the drug is generally 4-6 hrs per dose (25 mg come 50 mg).<2>

First generation antihistamines are known for their sedative effects and also CNS (central worried system) depressant effects. Many individuals cannot tolerate the sedative impacts of Benadryl (diphenhydramine) throughout the job and, therefore, just take it at bedtime to combat insomnia.

What Is NyQuil?

Nyquil is a combination cold/cough product that contains the medicine doxylamine, in addition to a pain/fever reducer (acetaminophen) and a sneeze suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and is in the same class of medication together Benadryl (diphenhydramine).<3>

Interaction Explained

As declared above, both doxylamine and Benadryl (diphenhydramine) work the same means and space actually in the same course of medication.

They work-related by blocking the histamine-1 receptor in the body, which avoids histamine indigenous binding come it and producing the symptoms we room all really familiar v (e.g. Runny nose, watery eyes, etc...).

Since both drugs work the very same way, using both in ~ the same time is no recommended.

Combined use normally won"t carry out any much more benefit than taking either alone. Additionally, taking them together not only increases the risk of excessive sedation, it considerably increases the risk of extr adverse effects such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high doses of sedating antihistamines have also been associated with excitation, agitation, and restlessness.<5>

When Is Use together Okay?

Having stated that, there can be a instance to take the mix together.

Benadryl (diphenhydramine) has reasonably strong proof for use in stemming allergy reactions.

Studies show that Benadryl (diphenhydramine) can effectively reduce itching and also swelling from reactions to things prefer bee stings and also poison ivy.

See more: Arabian Horses Have Black Skin So They Cannot Be Which Of These Colors? ?


If girlfriend have currently taken a dose of Nyquil and are having an allergic reaction come something, acquisition a dose of Benadryl (diphenhydramine) may aid without a huge increased danger in intolerable side effects.