Part 1

Which rat had actually the more quickly basal metabolic price (BMR)?

The common rat had actually the quicker basal metabolic rate, because it to be not missing its pituitary gland or its thyroid gland.

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Why walk the metabolic prices differ in between the regular rat and also the surgically changed rats? exactly how well walk the outcomes compare with your prediction? The regular rat has actually the highest possible BMR because it has the glands forced to stimulate and regulate the relax of thyroid hormones.

If an animal has been thyroidectomized, what hormone(s) would certainly be missing in the blood? Triiodothyronine and thyroxine.


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If an pet has been hypophysectomized, what effect would you suppose to see in the hormone level in that is body? because that the hypophysectomized rat, TSH would certainly be lacking due to the absent pituitary gland.

Part 2

What to be the impact of thyroxine injections ~ above the typical rat’s BMR? The levels were a little off. The typical rat to be hyperthyroidic since the thyroxine increases the metabolic rate but it did not construct a goiter.


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What was the result of thyroxine injections top top the thyroidectomized rat’s BMR? just how does the BMR in this case compare v the normal rat’s BMR? was the sheep of thyroxine in the syringe too large, also small, or simply right? The BMR increased for the thyroidectomized rat v the thyroxine injections.


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The BMR to be still a small bit under the typical rat’s BMR through thyroxine. The sheep was too low.

What was the effect of thyroxine injections on the hypophysectomized rat’s BMR? just how does the BMR in this instance compare v the typical rat’s BMR? was the dose of thyroxine in the syringe as well large, too small, or simply right? The BMR enhanced for the hypophysectomized rat through the thyroxine injections. The BMR to be still a small bit under the regular rat’s BMR v thyroxine. The sheep was as well low

Part 3

What was the impact of thyroid-stimulating hormone (TSH) injections top top the typical rat’s BMR? The result of TSH to be to increase the typical rat’s BMR

What to be the impact of TSH injections top top the thyroidectomized rat’s BMR? how does the BMR in this instance compare with the normal rat’s BMR? Why was this result observed? There to be no impact on the thyroidectomized rat’s BMR v the injection of TSH due to the fact that there was no thyroid gland come stimulate. What was the effect of TSH injections ~ above the hypophysectomized rat’s BMR? how does the BMR in this instance compare v the normal rat’s BMR? to be the sheep of TSH in the syringe too large, too small, or just right? The hypophysectomized rat’s BMR raised with TSH. The BMR to be just listed below the common rat’s BMR however still lower. The syringe amount was a small too low.

Part 4

What to be the effect of propylthiouracil (PTU) injections ~ above the typical rat’s BMR? Why go this rat develop a palpable goiter? The result of PTU injections top top the typical rat was to to decrease the BMR. The palpable goiter was due to buildup that the precursors of thyroxine. What to be the effect of PTU injections on the thyroidectomized rat’s BMR? how does the BMR in this instance compare v the typical rat’s BMR? Why was this effect observed? The result of PTU injections top top the thyroidectomized rat was not visible due to the fact that there was no thyroid gland to it is in affected. What was the impact of PTU injections top top the hypophysectomized rat’s BMR? just how does the BMR in this instance compare through the common rat’s BMR? Why to be this impact observed? The result of PTU injections on the hypophysectomized rat was not visible due to the fact that the rat is lacking the pituitary gland. Activity 2 Plasma Glucose, Insulin, and also Diabetes Mellitus

What is a glucose standard curve, and also why go you require to achieve one for this experiment? walk you appropriately predict how you would measure the quantity of plasma glucose in a patience sample making use of the glucose conventional curve? The glucose typical curve correlates the intensity of the color obtained and measured top top a spectrophotometer (optical density) to the glucose concentration. I m sorry patient(s) had glucose reading(s) in the diabetic range? can you say v certainty whether each of this patients has kind 1 or kind 2 diabetes? Why or why not? patience 3 and also 5 had actually a fasting plasma glucose in the diabetic range. Its not possible to call if lock have form 1 or type 2 diabetes just from their fasting plasma glucose. 3. Explain the diagnosis for patient 3, that was additionally pregnant at the moment of this assay. This would be defined as gestational diabetes which frequently disappears ~ the pregnancy. I m sorry patient(s) had actually normal glucose reading(s)?

Patient 1 and also 2 were in typical range.

What room some lifestyle choices these patients v normal plasma glucose readings might recommend to the borderline impaired patients? border the gulp down of an easy sugars. Choose good carbs such in its entirety wheat and fiber based carbohydrate choices. Practice regularly.

Activity 3 Hormone replacement Therapy

Why to be ovariectomized rats used in this experiment? exactly how does the fact that the rats room ovariectomized explain their baseline T scores? The ovaries produce estrogen and estrogen stimulates bone growth. Without estrogen bone growth is impaired and also osteoporosis is a common result. What impact did the administration of saline injections have actually on the manage rat? how well walk the results compare v your prediction? Saline had no effect. The inclusion of the saline as a an adverse control is come ensure that saline has no effect. What effect did the administration of estrogen injections have on the estrogen-treated rat? how well walk the results compare with your prediction? The estrogen injections did boost the rats vertebral bone density and is shown by the negative T score.

What effect did the administration of calcitonin injections have actually on the calcitonin-treated rat? exactly how well walk the results compare through your prediction? The calcitonin showed no readjust in the vertebral bone density. What space some health risks that postmenopausal ladies must think about when contemplating estrogen hormone replacement therapy? Health dangers of estrogen therapy incorporate an boosted incidence of uterine cancer, breast cancer, and also blood clots. Task Measuring Cortisol and Adrenocorticotropic Hormone 1 i beg your pardon patient would most most likely be diagnosed through Cushing’s disease? Why? Patient would be diagnosed bc the level of cortisol and also ACTH are both high.

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Which two patients have hormone levels characteristic the Cushing’s syndrome? patient 2 and 5 both have actually high level of cortisol and low ACTH. 3 patience 2 is gift treated for rheumatoid arthritis through prednisone. How does this information readjust the diagnosis? The diagnosis would adjust to iatrogenic or medical professional induced Cushings syndrome. 4 which patient would most likely be diagnosed with Addison’s disease? Why? patient 4 bc the level that ACTH is high yet the level of cortisol is low.