Which pains Reliever has a much faster Dissolution Time: Brand or Generic?
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Researched through Ashleigh R.

You are watching: Which pain reliever dissolves the fastest

2001-02

PURPOSE The function of this experiment to be to determine the dissolution time of three various pain relievers, compare brand name to generic names.

I came to be interested in this idea as soon as my family members is constantly suffering from headaches, and also don’t recognize which ache reliever functions fastest.

The information obtained from this experiment would advantage society; by informing lock which pain reliever is an ext easily dissolved.

HYPOTHESIS My very first hypothesis was the Ibuprofen would dissolve faster of every pain relievers.

I basic my hypothesis on the fact that numerous brand and also generic forms of pain relievers have different sugar coatings ~ above them, and also Ibuprofen doesn"t have really much of a coating.

My second hypothesis was that there would certainly be a difference between generic ibuprofen and brand name Advil.

I base my hypothesis on the fact again the Ibuprofen has actually a soft sugar coating, but Advil has actually a hard gel coating, thus meaning it will certainly take longer to acquire through Advil’s coating, to obtain to the actual pains reliever itself.

EXPERIMENT DESIGN The constants in this research were: * The quantity of water (125 ml) * The temperature that the water (36-37 levels Celsius) * lot of Hydrochloric mountain (100 ml) * The temperature the Hydrochloric acid (36-37 degrees Celsius) * place the experiment was performed * toughness of ache relievers (regular strength) * pH that simulated stomach acid * Test actions * Stirring method

The very first manipulated variable was the species of pains relievers used.

The second manipulated variable to be the brand name verses the generic form of each drug.

The responding variable was the time it took for each pains reliever come dissolve.

To measure the responding variable ns timed just how long the takes because that each pains reliever to dissolve in seconds, by a digital timer (stop watch).

MATERIALS
QuantityItem Description
1Stopwatch
2200 mL beakers
8Tablets of Acetaminophen
8Tablets of Tylenol
8Tablets that Aspirin
8Tablets of Bayer
8Tablets the Ibuprofen
8Tablets that Advil
1Pair the Latex gloves
1Microwave
2Magnetic stirrers
1Celsius thermometer
1Liter the simulated stomach acid (0.01 molar of simulated stomach acid, 0.10 grams every liter the amylase, and also 0.05 grams per liter that pepsin)
--Distilled Water
1Roll of document towels
1Apron
1Pair the goggles
11000 mL beaker
1Pen or Pencil
1Notebook to record results

PROCEDURES preparation 1. Placed on apron. 2. Placed on goggles. 3. Put on one pair the latex gloves. 4. Conference 1 Liter that simulated stomach acid. 5. Warm to 37* Celsius. 6. Conference 1 Liter the water. 7. Warm to 37* Celsius. CONDUCTING THE EXPERIMENT 8. Fill each beaker. 9. Then gather 2 200 ml beakers, and also fill v simulated stomach mountain to the 150 ml mark. 10. Location each maker (that is filled through simulated stomach acid) ~ above its very own magnetic stirrer. 11. Collection magnetic stirrer dial come the center of the dials variety of movement. 12. Drop the an initial tablet into one 200 ml maker simulated stomach acid and immediately begin the stopwatch. 13. Once a tablet computer is totally dissolved prevent the stop watch in which was timing it. 14. Document results ideal away. 15. Leaving the magnetic stirrer on. 16. Empty the end both beakers that the simulated stomach acid and also the dissolved tablets. 17. To wash all products in water. 18. Dry with file towels. 19. Repeat measures 10 through 18 three more times. 20. Climate repeat measures 10 with 23 other than using water instead of simulated stomach acid. RESULTS The initial purpose that this experiment was to recognize the dissolution times of three different pain relievers, comparing brand names and their share names.

The outcomes of the experiment were that all of the pills dissolved faster in distilled water than in gastric stomach acid. Bayer liquified fastest, adhered to by acetaminophen then Tylenol, climate Advil, following by Ibuprofen, and also finally Aspirin.

View my Data and Graphs Below.

CONCLUSION My very first hypothesis was the Ibuprofen would dissolve fastest of every pain relievers.

My second hypothesis was that there would certainly be a difference in between generic ibuprofen and also brand name Advil.

The results show that the first hypothesis should be rejected.

The results suggest that the very first hypothesis need to be accepted.

Because that the results of this experiment, ns wonder if water temperature or the speed of the magnetic stirrers could have to be a factor to bring about these results.

If i were to command this experiment again ns would have actually the weight of the magnets be the same, the magnetic stirrers be at specifically the very same spot top top the rate dial, i would save a much better log of mine experiment, I would certainly have much more samples of my experiment, ns would likewise make certain the liquid being provided stayed in ~ the very same temperature for the experiment.
RESEARCH REPORTIntroduction

ache relievers play a significant roll for human being all end the world. Whether it is taking medication for headaches or because that a cold they job-related to eliminate pain. To it is in effective, pain relievers should dissolve quickly so the body deserve to absorb them. Medicine medication is supplied to act illnesses. The score of medication is to conserve lives, improve health, and relieve suffering. In the mid 1800’s human being lived to the average age of fifty years old. Currently with the new advances in medicine people live to about 75 years old and many room still life 10 to twenty years past that age. Pain Relievers pains relievers are taken on regular basis by countless Americans. Ache relievers space drugs taken to relieve pain and also discomfort. The most frequently taken drugs are aspirin, acetaminophen, and ibuprofen. This drugs are classified together analgesics, drugs that relax pain without bring about loss that consciousness. Aspirin Aspirin additionally known as acetylsalicylic acid. The formula is C9H8O4, is a white odorless medication with a bitterness taste. Aspirin relieves pains such together headaches, arthritis, and also fever from infections. Today, aspirin is the most generally used medicine in the world, though it does have actually some cautions. Aspirin can reason irritation come the stomach lining, thus may result in stomach bleeding. Also, aspirin must not be offered to youngsters who have actually chicken pox or influenza, the kid could develop Reye’s Syndrome, i beg your pardon is disease that could cause serious damages to humans who are influenced by it. Aspirin is likewise sold under a various trade names (name that has actually the exact same ingredients just sold by a various company) of Bayer. Bayer has the same cautioning and relieves the same usual pains. Ibuprofen Ibuprofen reduce inflammation, fever, and also other pains. Ibuprofen functions by impede the development of prostaglandins (hormone prefer chemicals found throughout the body.) Ibuprofen has fewer side results than Aspirin, despite Ibuprofen can reason stomach irritation, which may cause minor stomach bleeding. Ibuprofen was developed in the 1960’s and also 1970’s. Strangely, if you’re allergy to Aspirin climate you"re most likely allergic to Ibuprofen. In the past, ibuprofen was doctor prescribed but now is sold over-the-counter. An extensive use of ibuprofen can cause ulcers and also stomach bleeding. Ibufrofen is not recommended because that pregnant women. If ib frames is take away excessively the may reason vomiting, diarrhea, rapid breathing, or fast heart beat, likewise it need to be avoided as soon as drinking alcohol addict beverages. A common trade name for ibufrofen is Advil. Advil is the very same medicine, just under a various name. Acetaminophen paracetamol is a frequently used drug about the world. The relieves soft pain and also fever, yet does not irritate the stomach, or interfere with blood clotting. Paracetamol is great when taken v a perceptible stomach, yet not once taken to minimize inflammation. Paracetamol can reason liver damages if taken in big amounts, and also death might occur. Acetaminophen is additionally sold under the name Tylenol. It was an initial introduced in 1893 under the name "Phenacetin," but came to be a prevalent drug in 1949. Acid words "Acid" comes from the Latin name "acetum," which way "vinegar." Acids space a huge group of vital chemicals that space usually corrosive, and have a cake taste. Acids room categorized right into two groups, necessary acids and also mineral acids. Common organic acids are things such as citrus juices, indigenous fruits favor oranges, and also lemons. Mineral acids are acids such together Hydrochloric, sulfuric, and nitric acids. Mineral acids space the solid acids, the strong acids dissociate almost totally once dissolving in water. Hydrochloric Acid Hydrochloric mountain is a highly corrosive, colorless, non-flammable gas. It has a suffocating odor, and also fumes strongly in moist air. Hydrochloric acid is do by molecules of hydrogen chloride ionize, becoming positively charged hydrogen ions and negatively charged chloride ions. Hydrochloric acid is uncovered close to the sight of erupting volcanoes, and is used for cleaning steel, and used come make usual plastics, such as vinyl and also PVC. Hydrochloric mountain is additionally known as "Muriatic acid" or "HCl." HCl can cause serious burns. Gastric Fluid Gastric fluid is likewise known together gastric juices. There are tiny amounts of hydrochloric acid in ours stomach linings, it is one of the key acids that failure food in our stomachs. Gastric liquid is do of hydrochloric acid and also an enzyme referred to as Pepsin. Water Water is the fluid of our lives. In fact it is the most common substance top top Earth. Water covers much more than seventy percent that the Earth, although just three percent of it is fresh water. The chemical surname of water is H2O, since it is one part hydrogen and two components oxygen. Solubility when dissolving, the largest quantity is the solvent, and also the smallest amount is the solute. The solvent is called the aqueous solution; the solute deserve to be gas, liquid, or a solid. In microscopes, solutions look homogenous. Homogenous way of the same or similar kind that nature, or being the very same throughout. Conclusion pains relievers have actually played a much more important roll in culture ever because they have been discovered. Water and hydrochloric mountain in the stomach fluids assist dissolve medications.

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BIBLIOGRAPHY

"Acetaminophen" Encarta 2000 "Analgesic." Encarta 2001 "Aspirin." Encarta 2000 Carter, Joseph L. Et al. "Solutions" physical Science. Massachusetts. Ginn and also Co. 1971. "Hydrochloric Acid." Encarta 2000 "Hydrogen Chloride." Encarta online. November 2, 2001 http://www.encarta.msn.com. "Ibuprofen" Encarta 2001. Johnson, Eugene M. "Acetaminophen." The World publication Encyclopedia. 2001 Johnson, Eugene M. "Ibuprofen." The World publication Encyclopedia. 1999. Johnson, Leonard R., et al., Eds. Physiology of the intestinal Tract. Raven Press. 1994 Keinath, thomas M. "Water." The World book Encyclopedia 1999. P. 116. Knapp, Brian. "Acids." Hydrogen and also Other Noble Gases. Connecticut Grolier Education/ Sherman Turnpike 1997. P. 18-19. Knapp, Brian. "Hydrochloric Acid." Hydrogen and Other Noble Gases. Connecticut. Grolier Educational/ Sherman Turnpike 1997. P. 22 - 23 "Life Expectancy" January 2002 http://www.gilbertling.org/Ikp4.htm "Medicine" The World publication Encyclopedia 1999. P. 363 "Pain Relievers." October 2001 http://encarta.msn.com. Robbins, Keith. "Aspirin." The World publication Encyclopedia. 1999. P. 816. Sladeck, N.E. "Aspirin." The World book Encyclopedia. November 2001 http://www.aolsvc.worldbook.aol.com/wbol/wbpage/ha/ar/co/033800. Smith, Carolyn J. "Hydrochloric Acid." The World book Encyclopedia. 1999. P. 465. "Solutions, Solubility, physics Properties." Encarta 2001.

ACKNOWLEDGEMENTS

I would like to say thanks to many civilization for help me complete this project. It would certainly not have actually been possible without them. * first of all i would prefer to say thanks to my mom and my grandma because that buying me tablets to complete my project. * following I would prefer to thank my dad because that picking me up everyday possible for after school sessions. * i would prefer to thank household friends for picking me up when my dad couldn’t do it to my after institution sessions. * i would favor to give thanks to Mr. Newkirk for helping me command my totality project, for remaining late day-to-day after institution to carry out my testing, likewise for helping me exactly my project over and over again until it was correct.