Professor Stig Steen’s love preservation technology shows success in transplanting hearts from pigs to baboons


A pig heart, displayed here,is very similar in size and anatomy to a human heart. For this reason, pigs space used broadly in pre-clinical pet testing for brand-new implantable cardiovascular devices. If pig hearts might be offered for human being transplantation, the wouldgreatly alleviate shortages that donor human being hearts.

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December 11, 2018 — The scientific journal Nature freshly published an write-up from Munich college Hospital which defines the irreversible survival that baboons that had received a love transplant from gene modified pigs.1 This is critical step front on the means to gift able to give humans porcine love transplants.

Pig hearts are very similar in size, anatomy and role to human being hearts, so are offered to train medical students. Porcine hearts space the gold-standard in pre-clinical animal testing for all cardiovascular gadgets prior to usage in people to both test the safety and also efficacy, and also refine the implant procedures.

The post describes two demands that have permitted the an excellent results. One of these needs is the development of non-ischemic heart preservation in accordance v the an approach using the products occurred by Prof. Stig Steen and also Swedish company XVIVO, and the other requirement is inhibition the post-transplantation expansion of the heart, i m sorry otherwise would come to be too big for the primate.

XVIVO owns every commercial rights to the modern technology and is submitting an application to the Swedish clinical Products firm as a prerequisite because that a multicenter examine on XVIVO’s commodities for heart preservation. The company plans to submit the application within approximately one month.

The XVIVO commodities consist of a preservation solution which has actually the very same composition together that clinically used in the love transplant study recurring at the university Hospitals the Lund, previously pre-clinical studies and also now pre-clinically supplied in Munich for heart preservation in xenotransplantation. The an innovation also has a portable love preservation maker incorporating a single-use component which has been constructed by XVIVO, in accordance v Steen’s technology.

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According to the united Network for organ Sharing (UNOS), a total of 3,133 love transplants have occurred in 2018, while 3,832 patient are right now waiting because that a brand-new heart,2 highlighting the require for creative solutions. An median of 20 civilization die every work while wait for an body organ transplant.2

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1. Längin M., Mayr T., Reichart B., et al. Regular success in life-supporting porcine cardiac xenotransplantation. Nature, published online Dec. 5, 2018. Https:// Accessed Dec. 11, 2018.